Tetanus Toxin

Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.

Also Known As:

Tetanus Toxins; Neurotoxin, Clostridial; Toxin, Clostridium tetani; Toxin, Tetanus; Toxins, Tetanus; Clostridial Neurotoxin; Clostridium tetani Toxin

Pharmalogical Action Categories:

Neurotoxins

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Bacterial Proteins: 394
    - Tetanus Toxin: 491
Biological Factors: 2472
- Biological Toxins: 20
  - Bacterial Toxins: 814
    - Tetanus Toxin: 491

K R van Kampen Selected Research

K R van Kampen Research Topics

Disease

Drug/Important Bio-Agent (IBA)